Scheme Information Sheets

UK NEQAS for Holotranscobalamin

Scheme Particulars Indicative Details
Accreditation body UKAS
ISO/IEC Accreditation status ISO/IEC 17043:2010
UKAS Accredited Proficiency Testing Provider No 7860
Objective of Scheme Provides EQA coverage by means of predominantly endogenous levels of Active B12/Holotranscobalamin and Methylmalonic Acid
Pre-, Analytical, Post- status Analytical/Post
Number of distributions per year (nominal) 11
Specimens per distribution 3
Number of Specimens per annum 33
Frequency of distribution Monthly
Scoring system ABC
Material distributed Pooled or single donations of liquid human serum with or without exogenous methyl malonic acid added
Programme Director(s) / Organiser(s) Finlay MacKenzie
Criteria for participation All, but overseas by courier
Nominal sample volume (mL) 0.5 ml
Sample presentation TACs All analytes in the same tube
Data in Chemistry on-line Dashboard Yes
Analyte Approx Range Default Units Target Value B Score Limit (%) C Score Limit (%)
HoloTC 10 – 150 pmol/L ALTM 15.0 15.0
HoloTC Interpretation ~ L, I, N or H ~ ~ ~
Methylmalonic acid 0 – 360 nmol/L ALTM ~ ~
Abbreviation Expansion
ALTM All Laboratory Trimmed Mean
GLTM Group Laboratory Trimmed Mean – which is the Method Principle Mean
MLTM Method Laboratory Trimmed Mean – usually a manufacturer system / analyser mean
XALTM An external value that may be from a Reference Method System
OGLTM A Method Principle Mean used as the target for all laboratories
OMLTM A specific Method Mean used as a target for all laboratories
MED Median

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